Regulatory Role of FGL-1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjogren Disease.

ABSTRACT:

Objective

Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.

Methods

We analyzed the influence of interorgan communication on the cellular or molecular mechanism of autoimmunity using a mouse model of primary Sjögren disease (pSjD) and patients with pSjD by integrative genomic, bioinformatic, pathologic, and immunologic analyses.

Results

Fibrinogen-like protein-1 (FGL-1) was identified as a potent factor for interorgan communication between the liver and immune system in pSjD model mice. The production of FGL-1 of the liver is induced by i

SUBMITTER: Otsuka K 

PROVIDER: S-EPMC12569741 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature