The relation of eye movements to the occurrence of freezing of gait in Parkinson's disease.

ABSTRACT: Freezing of gait is a debilitating motor symptom in Parkinson's disease that significantly increases fall risk and impairs quality of life. The poorly understood pathophysiology of freezing of gait presents challenges for early prediction and therapeutic intervention. This prospective study investigated whether eye movement abnormalities, specifically in the anti-saccade paradigm, could predict freezing of gait onset in Parkinson's disease patients over a two-year follow-up period. We analysed longitudinal data from the Ontario Neurodegenerative Disease Research Initiative, focusing on Parkinson's disease patients without freezing of gait at baseline who underwent comprehensive clinical evaluations and eye movement recordings. Anti-saccade reaction time and error ratio, combined with clini

SUBMITTER: Fernandez-Ruiz J 

PROVIDER: S-EPMC12569761 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature