Muscle loss phenotype predicts poor postoperative outcomes of colorectal cancer in US inpatients: a population-based analysis.

ABSTRACT:

Purpose

Muscle loss may lead to reduced therapy tolerance and survival. We aimed to assess whether colorectal cancer (CRC) patients with a muscle loss phenotype experience worse outcomes.

Methods

Data were extracted from the US Nationwide Inpatient Sample for hospitalized patients aged ≥20 years who underwent surgical resection for colorectal cancer (CRC) between 2005 and 2018. CRC and muscle loss phenotypes were identified using validated International Classification of Diseases (ICD) diagnosis and procedure codes. Propensity score matching was performed to balance characteristics. Regression analyses determined associations between muscle loss and in-hospital outcomes.

Results

A total of 209,171 patients were included, with a mean age of 67.9 years; 7.1% exhibited m

SUBMITTER: Lee KC 

PROVIDER: S-EPMC12569781 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature