Increased central serotonergic activity in patients after an acute ischemic stroke. An EEG study.

ABSTRACT:

Objective

Acute ischemic stroke (AIS) is often accompanied by functional impairments and post-stroke depression (PSD), affecting ∼30 % of patients. Since central serotonergic dysfunction may contribute to PSD, similar to major depressive disorder, we examined depressive symptoms and serotonergic neurotransmission after AIS using the loudness dependence of auditory evoked potentials (LDAEP), a non-invasive EEG marker.

Methods

19 patients with AIS and 18 age-matched healthy participants completed depression questionnaires (BDI, HAMD). LDAEP was assessed within 14 days after AIS and after three months, analyzed with mixed-models ANOVA.

Results

Shortly after AIS, patients showed lower LDAEP compared to controls for all electrodes (AIS M = 0.072 ± 0.077; controls

SUBMITTER: Flasbeck V 

PROVIDER: S-EPMC12569835 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature