Diagnostic Implications of Renin Reactivity in Confirmatory Tests: A Comparative Study of Direct Renin Concentration and Plasma Renin Activity in Primary Aldosteronism.

ABSTRACT:

Objective

Renin measurement is a key to diagnosing primary aldosteronism (PA). However, it remains unclear whether plasma renin activity (PRA) or direct renin concentration (DRC), which are based on different principles, offer superior performance. This study aimed to compare their diagnostic potential in PA.

Methods

This cross-sectional observational study was conducted at a single institution, and enrolled consecutive patients hospitalised for PA diagnosis. PRA and DRC were measured for the same samples during the captopril challenge, saline infusion, and furosemide upright tests. We evaluated renin responsiveness, defined as renin changes from baseline in each test, and the relationship between PRA and DRC.

Results

Seventy-two patients were classified into PA and n

SUBMITTER: Nagasaka T 

PROVIDER: S-EPMC12569981 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature