Near infrared II excitation conjugated polymers-based phototheranostic nanoplatform for hyperthermia-enhanced ferroptosis and immunotherapy.

ABSTRACT: Ferroptosis has the potential to induce immunogenic cell death (ICD) and remodel the immunosuppressive tumor microenvironment (TME). However, intracellular antioxidant glutathione (GSH) inhibits the efficacy of ferroptosis. Consequently, enhancing iron ion uptake while simultaneously depleting GSH presents a promising strategy to improve ferroptosis efficacy. Herein, we have developed phenylboronic acid-modified near infrared II photothermal therapy (NIR-II PTT) conjugated polymers DPP-CPDT-PBA (DCP), which co-load Fe²⁺ and GSH scavenger cisplatin (Pt), and encapsulate them within an amphiphilic DSPE-mPEG₂₀₀₀ to finally construct nanoplatform DCP@Pt@Fe. The formulated DCP@Pt@Fe exhibits outstanding NIR-II photothermal property and NIR-II imaging tracking capability. T

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12570039 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature