A LASSO-based predictive nomogram for obstructive coronary artery disease in double zero score patients: validation and cardiovascular education strategies.

ABSTRACT:

Background

This study aimed to create a nomogram to predict a double-zero score for obstructive coronary artery disease (CAD) in a hospital-based cohort initially scoring zero. We compared its diagnostic performance with the Framingham risk score (FRS) and models for atherosclerotic cardiovascular disease (ASCVD).

Methods

We retrospectively reviewed the clinical features and laboratory profiles of 634 participants with baseline zero coronary artery calcium scores. The target population consisted of individuals with a double-zero score. The primary endpoint was the diagnosis of obstructive CAD, defined as CAD-RADS ≥3 or vulnerable plaque formation on the second cardiac CT. The control group had a double-zero score, with no or less than 50% coronary stenosis. We developed a no

SUBMITTER: Liang CH 

PROVIDER: S-EPMC12570095 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature