Qingre huazhuo tang regulates IgA nephropathy through immune checkpoints and ferroptosis.

ABSTRACT:

Background

Qingre huazhuo tang (QRHZT) is a traditional Chinese medicine decoction that has been used clinically by traditional Chinese medicine masters for more than 50 years with good results. However, its mechanism is unknown, and further elucidation is necessary.

Aim of the study

To verify the mechanism by which QRHZT regulates IgA nephropathy through immune checkpoints and ferroptosis by combining network pharmacology, single-cell sequencing and experimental studies.

Materials and methods

The single-cell sequencing data obtained from podocytes of immunoglobulin A (IgA) nephropathy (IgAN) patients were screened, and the QRHZT target information was obtained from the ETCM database. Moreover, the KEGG, GSEA, immune checkpoint and ferroptosis data were analyzed and p

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12570100 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature