Identification of plasma tRNA-derived small RNA i-tRF-15:31-Lys-CTT-1 as a biomarker for diagnosis and prognosis of pulmonary arterial hypertension.

ABSTRACT:

Introduction

tRNA-derived small RNAs (tsRNAs) are emerging as noninvasive biomarkers of cellular damage. However, their role in pulmonary arterial hypertension (PAH) remains unclear.

Methods

Plasma i-tRF-15:31-Lys-CTT-1 levels were quantified in a discovery cohort (n = 141 PAH patients; n = 50 controls) and a verification cohort (n = 254 PAH patients; n = 70 controls). Diagnostic performance was assessed using receiver operating characteristic analysis, and survival outcomes were evaluated with Kaplan-Meier curves and multivariable Cox regression models.

Results

In discovery cohort, the median age was 41 years (IQR 27-54), with 65.9 % female and a median REVEAL 2.0 score of 7 (IQR 6-8). In verification cohort, the median age was 36 years (IQR 31-52), with 63.4 % femal

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12570165 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature