High-density atrial mapping, P-wave analysis, and computational simulations in Brugada syndrome: Enhancing the understanding of atrial fibrillation.

ABSTRACT:

Background

An increased risk of atrial fibrillation (AF) has been reported in patients with Brugada syndrome (BrS). The pathophysiology of AF susceptibility in BrS is largely unknown.

Objective

This study aimed to characterize the atrial electrical properties of patients with BrS with and without AF based on P-wave and high-density atrial mapping analysis with a focus on conduction velocity (CV) and provide mechanistic insights on AF susceptibility using computer modeling.

Methods

Electrocardiographic signals were processed, and P-wave parameters were analyzed in a consecutive series of patients with and without BrS. High-density atrial mapping was performed in patients with BrS undergoing an electrophysiological procedure. CV vectors were numerically approximated at

SUBMITTER: Zanchi B 

PROVIDER: S-EPMC12570171 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature