High-density evaluation of the arrhythmogenic substrate in persistent atrial fibrillation.

ABSTRACT:

Background

Left atrial (LA) fibrosis is a key component of arrhythmogenic remodeling in atrial fibrillation (AF). LA low-voltage areas (LVAs) are considered surrogates for fibrosis and novel targets for ablation. However, there are no established criteria for identifying such potential pathogenic areas, particularly when using omnipolar technology (OT) mapping.

Objective

This study aimed to evaluate the correlation between OT and conventional bipolar voltage (BiV) in AF and regular rhythms.

Methods

Bipolar and OT mapping was performed in 17 patients undergoing de novo ablation for persistent AF. Mapping was performed in AF and coronary sinus pacing (CSP) at 600 ms. BiV of <0.5 mV was defined as low voltage.

Results

LA voltage in AF correlated poorly with CSP us

SUBMITTER: Valli H 

PROVIDER: S-EPMC12570181 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature