Leukocyte telomere length mediates the association between SIRI and CKD: insights from NHANES 1999-2002.

ABSTRACT:

Background

Chronic kidney disease (CKD) is closely linked to systemic inflammation and accelerated cellular aging. However, the role of the systemic inflammation response index (SIRI) and leukocyte telomere length (LTL), a biomarker of cellular aging, in the development and progression of CKD remain incompletely elucidated.

Methods

We analyzed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) (1999-2002), which included 3805 individuals. Participants were divided into subgroups: (1) CKD versus non-CKD and (2) SIRI quartiles (Q1-Q4). SIRI was calculated as (monocytes × neutrophils)/lymphocytes. CKD was defined by urinary albumin to creatinine ratio (UACR) ≥30 mg/g or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m²

SUBMITTER: Dang X 

PROVIDER: S-EPMC12570250 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature