Isolated tricuspid Libman-Sacks endocarditis in a patient with systemic lupus erythematosus and antiphospholipid syndrome: case report.

ABSTRACT:

Background

Libman-Sacks endocarditis (LSE) is an immune-mediated, culture-negative valvulopathy complicating systemic lupus erythematosus (SLE) and often amplified by antiphospholipid syndrome (APS). Although classically left-sided, isolated tricuspid involvement is rare. Advanced three-dimensional (3-D) quantification refines tricuspid regurgitation (TR) grading and informs surgical timing.

Case summary

A 41-year-old woman with 2-year SLE and triple-positive secondary APS presented with 2 weeks of fever, migratory arthralgia, and a small non-traumatic subarachnoid haemorrhage (SAH). Serial blood cultures were negative. Transthoracic echocardiography showed multiple heterogeneous vegetations (largest 20 × 12 mm) on all tricuspid leaflets; 2-D PISA-EROA was 30 mm², while 3-D

SUBMITTER: Velasquez-Orozco GA 

PROVIDER: S-EPMC12570301 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature