Safety and immunomodulatory efficacy of heat-killed <i>Mycolicibacterium manresensis</i> as a novel paraprobiotic in swine.

ABSTRACT: Given the increasing global concern about antimicrobial resistance, it is necessary to identify nutritional alternatives to antibiotics and trace elements in the porcine industry. The present study was carried out to evaluate the safety and effect of the paraprobiotic heat-killed Mycolicibacterium manresensis (hkMm) in weaned piglets. For this purpose, twenty-four-week-old piglets, were assigned to four experimental groups, and the diet of three of them was supplemented with 10, 50 and 100 ppm of hkMm, respectively, during a period of 70 d. Animals were monitored throughout the experiment, and weight data, blood, serum and saliva samples were collected every 2 weeks. At the end of the study, tissue samples were collected for histopathology, histomorphometry, immunohistochemical, and

SUBMITTER: Alvarez-Delgado C 

PROVIDER: S-EPMC12570335 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature