Spinning Green: Lipase-Catalyzed Synthesis of Bioactive Fatty Acid Amides from Renewable Lipid Feedstocks in a Rotating Bed Reactor.

ABSTRACT: Fatty acid ethanolamides (FAEAs) are bioactive lipids involved in inflammation, pain modulation, and energy homeostasis, gaining interest in the pharmaceutical, nutraceutical, and cosmetic sectors. Here, we present an intensified biocatalytic strategy for the synthesis of a mixture of FAEAspalmitoylethanolamide (PEA), oleoylethanolamide (OLA), stearoylethanolamide (SEA), and linoleoylethanolamide (LEA)starting from microbial lipids extracted fromCutaneotrichosporon oleaginosus, cultivated on whey permeate, a major dairy byproduct, supplemented with waste cooking oil. The two-step enzymatic cascadetransesterification of triacylglycerols into ethyl esters followed by aminolysis with ethanolaminewas catalyzed by Novozym 435 (immobilized Candida antarctica lipase B) in green

SUBMITTER: Bigliardi M 

PROVIDER: S-EPMC12570363 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature