Utility of alternative specimens in the diagnosis of pulmonary tuberculosis in people living with human immunodeficiency virus in Guinea.

ABSTRACT:

Background

Tuberculosis (TB) remains under-diagnosed in people living with HIV (PLHIV) and is a major cause of mortality in these population. Sputum is the primary specimen for TB diagnosis; however, many PLHIV are unable to produce quality sputum. This study assessed the diagnostic utility of alternative non-invasive specimens, stool, and urine, for TB detection in PLHIV using the Xpert MTB/RIF Ultra assay.

Methods

A cross-sectional study was conducted in TB screening and treatment centres in Conakry, Guinea, including 300 PLHIV presumptive pulmonary TB. Sputum, stool, and urine specimens were collected and tested using the Xpert MTB/RIF Ultra assay. Diagnostic performance was assessed in terms of sensitivity, specificity, and positive and negative predictive values, with t

SUBMITTER: Diallo BD 

PROVIDER: S-EPMC12570420 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature