<i>Candida albicans</i> Hxk1 influences expression of metabolic- and virulence-related genes.

ABSTRACT: The Hxk1 protein of Candida albicans phosphorylates N-acetylglucosamine (GlcNAc) which is necessary for various cellular functions, including energy production and chitin synthesis. Further, this protein also regulates morphogenesis independently of its role in GlcNAc catabolism. When HXK1 is deleted, cells are hyperfilamentous on serum-containing medium. Furthermore, Hxk1 translocates to the nucleus in the presence of glucose. To gain a broad understanding of the effect of Hxk1 on gene expression in C. albicans, we performed genome-wide transcriptional profiling of the hxk1 mutant strain by RNA-Seq. The analysis of these RNA-Seq data showed that Hxk1 affects gene expression in both a carbon source-dependent and -independent manner. However, the effect on gene e

SUBMITTER: Wijnants S 

PROVIDER: S-EPMC12570500 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature