<i>Candida auris</i> persists in the vaginal microaerobic niche in the absence of interleukin-17A.

ABSTRACT: Candida auris is an emerging fungus notable for its high drug resistance and persistent colonization of human hosts and environmental surfaces. However, its role in vulvovaginal candidiasis (VVC), a common form of superficial candidiasis, remains poorly understood. In this study, we investigated the colonization capacity of C. auris and vaginal defense mechanisms in a VVC model. Using an estrogenized VVC mouse model, we evaluated fungal burden, inflammatory cell counts, and S100A8 concentrations in vaginal lavages of wild-type (WT) and IL-17A knockout (Il17a^-/-) C57BL/6J mice following C. auris inoculation. Histopathological examination and flow cytometry analysis of vaginal immune cells were also conducted. Additionally, an in vitro adhesion a

SUBMITTER: Abe M 

PROVIDER: S-EPMC12570508 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature