Comparative evaluation of hyaluronic acid and injectable platelet-rich fibrin in palatal wound healing: a randomized clinical trial.

ABSTRACT:

Objectives

This study aimed to compare the effects of locally applied hyaluronic acid (HA) and injectable platelet-rich fibrin (I-PRF) on patient morbidity, oral health-related quality of life (OHRQoL), and healing of palatal donor sites, palatal tissue consistency, complete epithelization (CE), and color match (CM).

Materials and methods

Sixty-seven patients undergoing free gingival grafting (FGG) were randomly assigned to three groups in an examiner-masked clinical trial. Test group 1 received a 0.8% HA gel-impregnated gelatin sponge, test group 2 received an I-PRF-impregnated sponge, and the control group received a sterile sponge. Pain and burning were assessed via a visual analog scale (VAS) on days 3, 7, 14, and 21. CM was evaluated on days 3, 7, 14, 21, 28, and at mon

SUBMITTER: Ceylan Sen S 

PROVIDER: S-EPMC12570640 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature