Plasma proteomics uncovers divergent molecular signatures in ischemic stroke and intracerebral hemorrhage.

ABSTRACT:

Background

Timely differentiation between ischemic stroke (IS) and intracerebral hemorrhage (ICH) is critical for guiding appropriate acute management strategies. While neuroimaging is the diagnostic gold standard, its accessibility is often limited in urgent clinical settings. Blood biomarkers offer a promising, scalable diagnostic alternative; however, no validated panel is yet available for distinguishing stroke subtypes during the hyperacute phase.

Methods

In a multicenter study, plasma samples were collected within 6 h of symptom onset. A total of 3,072 proteins were measured using Olink® proximity extension assays. We applied differential expression analysis, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and receiver operatin

SUBMITTER: Nunez-Jurado D 

PROVIDER: S-EPMC12570678 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature