Inappropriate GFR equations misrepresent CKD epidemiology and risk interpretation in scientific reports.

ABSTRACT:

Background

The accuracy of chronic kidney disease (CKD) prevalence and its associations with metabolic risk factors depends heavily on the formula used to estimate glomerular filtration rate (eGFR). In Iran, many epidemiologic studies still rely on outdated equations, which may distort epidemiologic findings and misinform public health estimates.

Methods

We analyzed 9,911 adults from the Fasa Adult Cohort Study (FACS) at baseline and 2,977 at 5-year follow-up. eGFR was calculated using Cockcroft-Gault, MDRD, and CKD-EPI 2021 equations. CKD was defined as eGFR < 60 mL/min/1.73 m². Associations of metabolic dysfunction-associated steatotic liver disease (MASLD) and the fatty liver index (FLI) with CKD prevalence and incidence were examined using logistic regression, with polyn

SUBMITTER: Bazmi S 

PROVIDER: S-EPMC12570679 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature