Differential impact of lipid levels on the association between homocysteine and new-onset atrial fibrillation in acute myocardial infarction patients.

ABSTRACT:

Background

Homocysteine (Hcy) and dyslipidemia are both established risk factors for cardiovascular disease. However, their interaction in the development of new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI)-especially across different baseline LDL-C levels-is not well-understood.

Methods

This retrospective cohort study included 3,257 AMI patients. Within both normal lipid and dyslipidemia groups, participants were stratified by Hcy tertiles. Spearman correlation analysis was employed to examine the relationship between Hcy and lipid profiles. Multivariable logistic regression and generalized additive models with smooth curve fitting were utilized to investigate the association between Hcy levels and NOAF across varying baseline LDL-C profiles. Sen

SUBMITTER: Wu P 

PROVIDER: S-EPMC12570706 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature