Establishment of disseminated neonatal echovirus 11 infection model in hFcRn transgenic mice.

ABSTRACT: Echovirus 11 (E11) infections can easily cause neonatal sepsis, which is a life-threatening disease. However, the pathogenesis of E11 infections remains poorly understood. Furthermore, the absence of an effective animal model that accurately reflects disseminated neonatal infection has hindered research progress. Hence, we aimed to establish a precise disease mouse model closely resembling E11 associated human neonatal conditions. Three-day-old human neonatal Fc receptor (hFcRn) transgenic mice were administered an optimized dose of E11 through intraperitoneal (IP) injection. E11-infected mice exhibited severe clinical symptoms, including weight loss, limb paralysis, and even death. Viral loads were detected across multiple organs, such as muscle, spinal cord, and intestine, with the highe

SUBMITTER: Li F 

PROVIDER: S-EPMC12570726 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature