Comprehensive analysis of metabolic and molecular alterations in the blood of patients with Sjogren's syndrome based on untargeted metabolomics analysis.

ABSTRACT:

Background

Sjögren's syndrome (SS) is a chronic autoimmune disorder marked by lymphocytic infiltration of exocrine glands, leading to xerostomia, keratoconjunctivitis sicca, and systemic involvement including fatigue, arthralgia, and visceral organ impairment. Its pathogenesis reflects a multifactorial interaction of genetic, environmental, and hormonal influences that collectively disrupt immune homeostasis and drive tissue injury. Extensive investigations remain essential to clarify molecular pathways and establish reliable biomarkers that can enable early detection and precision therapy in SS. Detailed characterization of metabolic and molecular disturbances associated with SS is indispensable for advancing both pathophysiological insight and clinical management.

Material and

SUBMITTER: Liu J 

PROVIDER: S-EPMC12570844 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature