The effectiveness of hydrogel matrix containing nitric oxide, silver nanoparticles, vancomycin, and ciprofloxacin on methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa biofilm isolated from patients with chronic rhinosinusitis.

ABSTRACT:

Background

Many scientists are studying chronic rhinosinusitis (CRS) due to its high relapse incidence and drug resistance. We investigated the antibiofilm activity and sustained co-release of nitric oxide, silver nanoparticles, vancomycin, and ciprofloxacin in thermosensitive hydrogel (HyNSVC) for bacterial CRS.

Methods

To identify and isolate Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA), samples were taken from 10 patients with CRS who underwent Functional Endoscopic Sinus Surgery (FESS), and then they were diagnosed using culture and molecular methods. The HyNSVC was synthesized, and its physicochemical characteristics were evaluated using different methods. The broth microdilution assay and the MTP (microtiter plate) method assessed the m

SUBMITTER: Chegini Z 

PROVIDER: S-EPMC12570856 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature