Comparing the analgesic efficacy of liposomal bupivacaine versus bupivacaine for postoperative pain management in breast surgery: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Effective management of postoperative pain is essential for enhancing recovery and improving patient satisfaction after breast surgery. Traditionally, bupivacaine, a long-acting local anaesthetic, has been widely employed for this purpose. More recently, liposomal bupivacaine, a novel prolonged-release formulation, has been introduced as a potential alternative. Although several randomised controlled trials (RCTs) have evaluated these agents, their comparative efficacy remains uncertain. This protocol describes the methodology for a systematic review and meta-analysis designed to assess the analgesic effectiveness of conventional bupivacaine versus liposomal bupivacaine in the setting of breast surgery.

Method and analysis

This study is designed as a systematic

SUBMITTER: Jiao B 

PROVIDER: S-EPMC12570905 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature