Combination Diagnostics In Vivo: Dual-Mode Ultrasound/NIR Fluorescence Imaging with Neodymium- and Thulium-Doped Graphene Quantum Dots.

ABSTRACT: The combination of two biomedical imaging techniques, fluorescence and ultrasound imaging, can uniquely offer enhanced anatomical visualization, sensitivity, and specificity necessary for improved diagnostic accuracy in detecting small tumors, tracing therapeutic delivery, and guiding biopsies. This work aims to harness the advantages of highly deterministic fluorescence imaging and deeply penetrating ultrasound diagnostics in neodymium- and thulium-doped graphene quantum dot (Nd-NGQD and Tm-NGQD) ultrasound/near-infrared (NIR) fluorescence contrast agents. These biocompatible nanostructures are tested for dual-mode fluorescence/ultrasound imaging in vivo in live sedated BALB/c mice as well as in animal organs. Injected intravenously (IV), Tm-NGQDs and Nd-NGQDs exhibit ultrasound enhanceme

SUBMITTER: Valimukhametova A 

PROVIDER: S-EPMC12571052 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature