Covering All Bases: A Universal Metazoan UCE Probe Set to Democratize Phylogenomics.

ABSTRACT: Biology is in a genomics era, but many researchers may still be alienated from these techniques as a lack of genomic resources remains for many animal groups, necessitating further democratization. Hybrid capture is a popular phylogenomic approach in molecular systematics, with ultraconserved elements being the most popular. However, access to ultraconserved element data is more expensive per sample relative to other commonly used genetic/genomic approaches. Using published genomes, we developed a metazoan ultraconserved element probe set, the universality of which allows multiple research groups working on vastly different animal lineages to share costs and resources across labs. We demonstrated the utility of this probe set both in silico against 58 published metazoan genomes and in vitr

SUBMITTER: Derkarabetian S 

PROVIDER: S-EPMC12571155 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature