Subcortical brain abnormalities and cognitive function in individuals with psychosis and their unaffected relatives: A normative modeling approach.

ABSTRACT: Previous research has shown subcortical aberrations in individuals with psychosis (probands) and their unaffected first-degree relatives. However, few studies directly evaluated whether the pattern of aberration is similar across multiple subcortical regions and across probands and relatives, and whether the relationship between subcortical aberrations and cognition is similar between probands and unaffected relatives. To address these questions, this study employed a normative modeling approach and examined deviation scores of five subcortical regions from the normative range of 127 probands, 86 unaffected relatives, and 50 controls from the Psychosis Human Connectome Project. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). The pattern o

SUBMITTER: Stanica AM 

PROVIDER: S-EPMC12571197 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature