Visible-Light-Driven TiO₂/Pt Nanozyme-Embedded Dressings: Integrating PDT, Oxygenation, and Biomechanical Support for Pressure Ulcer Repair.

ABSTRACT: Pressure ulcer (PU) cause metabolic disorders and ischemia via prolonged pressure, leading to secondary infection, inflammation, and vascular neuropathy. However, existing therapies rely on microenvironment, H₂O₂, low repair efficiency, and lack efficient collaborative therapy. Herein, a confined multifunctional TiO₂/Pt nanozyme is developed via atomic layer deposition for PUs repair. Pt doping narrowed the TiO₂ bandgap (3.30→3.05 eV), enhance visible-light-driven •OH generation, and achieves 100% and 97.38% antibacterial efficacy against E. coli and S. aureus by visible photodynamic therapy (PDT). Demonstrating robust CAT/SOD-like activities, it neutralizes ROS in wound microenvironments. For clinical translation, the nanozyme is embedded into a

SUBMITTER: Yang J 

PROVIDER: S-EPMC12571212 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature