Impact of histone post-translational modification inhibitors on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas.

ABSTRACT: Epigenetic modifications, including histone post-translational modifications, are central drivers of age-associated structural and functional changes in the genome, influencing gene expression and leading to changes in cellular resilience. Epigenetic modifications are thus a target for therapies to prevent or treat age-related decline in health and lifespan. In this study, we measured the effects of inhibiting histone deacetylases (HDACs) and the histone methyltransferase, SETDB1, on lifespan, reproduction, and stress response in the rotifer Brachionus manjavacas, a model organism for aging studies. Rotifers were exposed to three pharmaceutical compounds, the HDAC inhibitors β-hydroxybutyrate and sodium butyrate and the SETDB1 inhibitor mithramycin A. Changes in global histone modification

SUBMITTER: Luviano Aparicio N 

PROVIDER: S-EPMC12571253 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature