Short term hemodynamic effects of atrial fibrillation in a closed-loop human cardiac-baroreflex system.

ABSTRACT: Atrial fibrillation (AF) remains the leading cardiac cause of stroke and AF-related death rate in the United States has been increasing for over twenty years. While the effect of standalone AF on heart rate is well established, there is a lack of clarity on its impact on other critical hemodynamic metrics. This is ostensibly due to interaction with other common comorbidities, especially hypertension. In addition, AF has a complex relationship with the state of the baroreflex. Evidence indicates that baroreflex sensitivity (BRS), the ability of the intrinsic cardiac control system to initiate parasympathetic response, is suppressed during AF. Therefore, a proper assessment of the hemodynamic impact of AF must take the state of the baroreflex into consideration. In this paper, we present a l

SUBMITTER: Adeodu O 

PROVIDER: S-EPMC12571259 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature