Association of perchlorate, nitrate, and thiocyanate with age-related macular degeneration in the United States.

ABSTRACT: Perchlorate, nitrate, and thiocyanate are endocrine-disrupting chemicals, but their associations with AMD is unclear. This study aims to investigate this relationship. We included 4727 participants aged 40 years and older from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Logistic regression analysis, restricted cubic spline (RCS), and weighted quantile sum (WQS) were applied to investigate the single, non-linear, and combined effects on AMD risk. Nitrate exposure was positively associated with any AMD risk (OR Any AMD, 1.19; 95% CI, 1.05-1.35; P = 0.010) and early AMD risk (OR Early AMD, 1.19; 95% CI, 1.05-1.36; P = 0.010); compared to the first quartile, the highest quartile of nitrate (OR, 1.94; 95% CI, 1.18-3.19; P = 0.012) and thiocyanate (OR, 1.70; 95% CI,

SUBMITTER: Jia S 

PROVIDER: S-EPMC12571269 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature