Comparison of PSA Values from capillary dried blood spot analysis and venous serum samples.

ABSTRACT: Prostate-specific antigen (PSA) testing is a key tool in the early detection and monitoring of prostate cancer. While venous blood is the standard matrix for PSA measurement, capillary blood sampling represents a minimally invasive alternative that may facilitate broader access to testing. This prospective study investigated the agreement between capillary and venous measurements of total and free PSA in 224 male patients at ALTA Klinik Bielefeld, Germany. Blood samples were collected between April and June 2021 and analyzed using electrochemiluminescence immunoassays. The results showed strong correlations between capillary and venous samples for both total PSA (r = 0.99, p < 0.01) and free PSA (r = 0.98, p < 0.01). Mean differences were 0.35 ng/mL for total PSA and 0.27 ng/mL for free PS

SUBMITTER: Engelage L 

PROVIDER: S-EPMC12571311 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature