Clinicopathological Prognostic Model for Survival in Adult Patients With Secondary Hemophagocytic Lymphohistiocytosis.

ABSTRACT:

Background

Data on bone marrow (BM) findings in secondary hemophagocytic lymphohistiocytosis (sHLH) and their association with overall survival (OS) are limited.

Objectives

This study aimed to develop a prognostic model incorporating BM findings and clinico-laboratory factors affecting OS.

Methods

We retrospectively evaluated 50 adults with sHLH and developed a clinicopathological prognostic model based on survival-associated factors.

Results

Most patients demonstrated normocellular BM (46.3%) and mild hemophagocytic activity (44.2%). Factors associated with survival in multivariable analyses (MVA) were age above 70 years (hazard ratio [HR] 3.89, p = 0.016), infection-related (HR 4.62, p = 0.006), hemoglobin < 7 g/dL (HR 5.21, p < 0.001), and hypocellular marro

SUBMITTER: Vittayawacharin P 

PROVIDER: S-EPMC12571457 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature