Sex-specific prognostic value of automated epicardial adipose tissue quantification on serial lung cancer screening chest computed tomography.

ABSTRACT:

Aims

Epicardial adipose tissue (EAT) is a metabolically active fat depot associated with coronary atherosclerosis and cardiovascular (CV) risk. While EAT is a known prognostic marker in lung cancer screening, its sex-specific prognostic value remains unclear. This study investigated sex differences in the prognostic utility of serial EAT measurements on low-dose chest computed tomography (CT).

Methods and results

We analysed baseline and 2-year changes in EAT volume and density using a validated automated deep-learning algorithm in 24 008 heavy-smoking participants from the National Lung Screening Trial (NLST). Sex-stratified multivariable Cox models, adjusted for CV risk factors, body mass index (BMI), and coronary artery calcium (CAC), assessed associations between EAT and

SUBMITTER: Brendel JM 

PROVIDER: S-EPMC12571501 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature