The comparative prevalence of comorbidities across rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis.

ABSTRACT:

Objectives

Inflammatory arthritis (IA) is associated with a high comorbidity burden, yet few studies have compared comorbidities across IA subtypes. We aimed to compare 39 comorbidities across RA, PsA and axial spondyloarthritis (axSpA).

Methods

We used UK Biobank data from over 500 000 participants aged 40-69 years. Baseline data for IA and comorbidities were identified via ICD-10 codes, primary care records and/or self-report. Analysis of variance (ANOVA) and chi-squared tests were used for group comparisons, and logistic regression was used to estimate adjusted odds ratios (ORs) for comorbidities in IA versus controls.

Results

Of 230 055 participants (45.4% male; mean age 56.5 years), 1969 had RA, 606 PsA and 797 axSpA. Hypertension (prevalence 9.0-11.1%) and dyspe

SUBMITTER: Williams JC 

PROVIDER: S-EPMC12571505 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature