Impact of endurance training on mitochondrial H₂O₂ production and NRF2 levels in different rat organs.

ABSTRACT:

Background

In recent years, increasing attention has focused on the effect of exercise on redox balance and the expression of nuclear factor erythroid 2-related factor 2 (NRF2), widely recognized as the master regulator of antioxidant defense mechanisms. However, surprisingly little is known about how physical training influences H₂O₂ production and NRF2 expression across various vital organs.

Methods

We investigated the effects of endurance training on the oxidative capacity, reactive oxygen species production, and antioxidant defense of various body organs in rats. Sixteen 4-month-old male Wistar rats were randomly assigned to either an endurance training group (8 weeks of treadmill running, n = 8) or a sedentary control group (n = 8).

SUBMITTER: Galganski L 

PROVIDER: S-EPMC12571570 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature