Brain-clinical signatures of basal ganglia-related dysfunctional reorganisation in Parkinson's disease.

ABSTRACT:

Background

The hierarchical organisation of functional networks is crucial for integration and segregation, and its dysregulation is implicated in neurodegenerative progression. The basal ganglia (BG) is the communication hub of the BG-thalamo-cortical circuit, and its dysfunction drives the progression of clinical symptoms in Parkinson's disease (PD). However, network-level functional reorganisation of BG disruption remains unclear.

Methods

In this cross-sectional study, we applied functional gradient analysis based on a diffusion map embedding algorithm to delineate macroscale functional architectures of BG in 102 PD patients and 88 healthy controls (HCs). Partial least squares correlation analysis was employed to investigate the relationship between gradient alterations a

SUBMITTER: Chen L 

PROVIDER: S-EPMC12571575 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature