Mitochondrial quality control in neurodegenerative diseases: from molecular mechanisms to natural product therapies.

ABSTRACT:

Background

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, etc., are a group of complex and heterogeneous disorders characterized by progressive synaptic loss and pathological protein alterations. Mitochondria are the main source of energy produced by neurons and support the high energy consumption of the nervous system. Mitochondrial quality control, involving processes like mitophagy and mitochondrial biogenesis, is crucial for mitochondrial homeostasis, and mitochondrial dysfunction is closely related to neurodegenerative diseases pathogenesis, making targeting mitochondrial quality control a potential therapeutic strategy. Natural products offer benefits such as cost-effectiveness, fewer side effects, and other positive qualities, making the

SUBMITTER: Chen B 

PROVIDER: S-EPMC12571580 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature