RARRES1 attenuates H₂O₂-induced RPE cell injury and inhibits choroidal neovascularization.

ABSTRACT:

Introduction

Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss in the elderly, yet its underlying molecular mechanisms remain incompletely understood, and novel biomarkers and therapeutic targets are urgently needed. This study aimed to identify and functionally characterize potential biomarkers and therapeutic candidates for nAMD, with a focus on retinoic acid receptor responder protein 1 (RARRES1).

Methods

Tandem mass tag (TMT)-based proteomic analysis was performed on aqueous humor samples from patients with nAMD and age-related cataracts. RARRES1 expression was examined in aqueous humor, laser-induced choroidal neovascularization (CNV) model mice, and human ARPE-19 cells exposed to H₂O₂. Functional studies assesse

SUBMITTER: Li Y 

PROVIDER: S-EPMC12571599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature