Night shift work increases the risk of developing irritable bowel syndrome: a prospective cohort study in the UK Biobank.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with a substantial disease burden. Night shift work has become increasingly common and is related to various human diseases. This study investigates the relationship between night shift work and the risk of incident IBS.

Methods

266,605 participants from the UK Biobank were included in our analysis. Data on shift work patterns, IBS incidence, and relevant covariates were obtained from the UK Biobank. Cox proportional hazard regression models were employed to assess the association between night shift work and IBS risk. Sensitivity analysis and subgroup analysis stratified by specific covariates were conducted to evaluate the robustness of the findings.

Results

During a media

SUBMITTER: Lu S 

PROVIDER: S-EPMC12571640 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature