Intergenerational effects of dietary iron on swimming and metabolic performance in zebrafish.

ABSTRACT: Iron is an essential trace metal required for various physiological processes, yet both deficiency and excess can disrupt metal homeostasis and compromise fitness. In this study, we investigated how dietary iron availability influences physiological performance across generations in zebrafish (Danio rerio). Fish were fed diets spanning a gradient from deficiency to supplementation (Low Fe, 11 mg Fe/kg; Medium Fe, 420 mg Fe/kg, and High Fe, 2,300 mg Fe/kg), and effects on growth, metal homeostasis, swimming performance, energy metabolism, and reproduction were assessed. Following reproductive assays, offspring were raised under control conditions and subsequently challenged with the same dietary iron treatments (Low Fe, Medium Fe, and High Fe as parents) in adulthood. Sub-acute expos

SUBMITTER: Chandrapalan T 

PROVIDER: S-EPMC12571662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature