The effect of metformin in clinical studies on knee osteoarthritis: an updated systematic review and meta-analysis.

ABSTRACT:

Objectives

Metformin is regarded as a potential drug for the treatment of knee osteoarthritis (KOA), but its efficacy remains unclear. This systematic review and meta-analysis aims to evaluate the efficacy of metformin in the treatment of KOA.

Methods

According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched three literature databases, including PubMed, Web of Science and EMBASE, and conducted a systematic review and meta-analysis of randomized controlled trials and cohort studies up to April 1, 2025, studies evaluating the use of metformin in the treatment of KOA were included. Hazard ratio (RR), standard mean difference (SMD), and the corresponding 95% confidence interval (CI) were used as aggregated statistics. This s

SUBMITTER: Guo X 

PROVIDER: S-EPMC12571718 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature