Clinical features and prognosis of the adult patients positive for both N-methyl-d-aspartate receptor and myelin oligodendrocyte glycoprotein antibodies.

ABSTRACT:

Introduction

The coexistence of the MOG antibody (MOG-ab) and NMDAR antibody (NMDAR-ab), which is known as the MOG-ab and NMDAR-ab overlapping syndrome (MNOS), is the most common in overlapping syndromes of neural autoantibodies. The study aimed to analyze the clinical features and outcomes in adult patients suffering from MNOS and investigate the mechanisms of the disorder.

Methods

Adult patients suffering from MNOS admitted to the Affiliated Brain Hospital of Nanjing Medical University from 2020 to 2024 was systematically reviewed. The clinical symptoms, laboratory data, imaging results, treatments, and prognoses were evaluated. Moreover, the clinical data of MNOS patients were compared with those of anti-NMDAR encephalitis (anti-NMDARE) patients and MOG antibody-associate

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12571725 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature