Gut microbiome-mediated epigenetic modifications in gastric cancer: a comprehensive multiomics analysis.

ABSTRACT:

Background

Gastric cancer (GC), a malignant and highly proliferative disease, has profoundly impacts a substantial global population and is associated with several variables, including genetic, epigenetic, and environmental impacts. Global variance is associated with Helicobacter pylori infection and dietary factors.

Objectives

The aim of the present study was to understand and identify key genes significantly modulated by epigenetic changes that can serve as biomarkers and therapeutic targets for gastric cancer.

Methods

This study employed an integrative multiomics approach to investigate gut microbiome-mediated epigenetic modifications in gastric cancer by utilizing publicly available transcriptomic and DNA methylation datasets, Quality control, normalization

SUBMITTER: Qian Z 

PROVIDER: S-EPMC12571729 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature