LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment.

ABSTRACT:

Introduction

The concept of cognitive resilience (CR) has emerged to explain the lack of correlation between the extent of brain lesions and the severity of cognitive symptoms in Alzheimer's disease (AD), but the underlying mechanisms remain poorly understood.

Methods

To investigate this, we developed a preclinical model of CR using a sporadic model of AD in a specific rat strain named LOU/c/jall described as a successful aging model. LOU/c/jall and Wistar control rats were bilaterally injected with streptozotocin (STZ; 3 mg/kg) or a vehicle solution into the cerebral ventricles. Cognitive performance and neuropathological examinations were evaluated 1 month after surgery.

Results

Our results showed that STZ-injected Wistar exhibited greater cognitive deficits than LO

SUBMITTER: Gephine L 

PROVIDER: S-EPMC12571741 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature