Brain Network Signature of Autoscopic Phenomena in Humans.

ABSTRACT:

Aims

Autoscopic phenomena (AP) are distinct manifestations of epileptic seizure semiology and are also identified in diverse psychiatric disorders. Our study aimed to map the brain AP network and characterize its multimodal signatures.

Methods

By performing lesion network mapping using the human connectome dataset (n = 1000), we investigated the brain AP network derived from 25 cases of AP caused by distributed focal brain lesions (n = 19) and direct electrical stimulation (DES) (n = 6). We further studied the multimodal signatures of the AP network, including exploring spatial correlation with human cortical developmental and evolutionary expansions, neurotransmitters, and electrophysiological rhythms.

Results

We mapped a common AP network primarily involving the bil

SUBMITTER: Wang S 

PROVIDER: S-EPMC12571770 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature