A bibliometric analysis and systematic review of drug repurposing against drug-resistant ESKAPE pathogens: a particular focus on <i>Pseudomonas aeruginosa</i>.

ABSTRACT:

Purpose

Drug-resistant ESKAPE pathogens represent a major global health challenge. This study included a comprehensive bibliometric analysis and systematic review to evaluate drug repurposing efforts against these pathogens, with a particular focus on Pseudomonas aeruginosa.

Methods

We searched the Web of Science Core Collection (2001-April 2025) using the query "ESKAPE AND Drug Resistance AND Drug Repositioning" and performed bibliometric analysis with Bibliometrix (RStudio 4.3.2), VOSviewer 1.6.20, and CiteSpace 6.2R6. In parallel, a systematic review was conducted across PubMed, Embase, Web of Science, and Cochrane Library to identify non-antibiotic agents with reported activity against resistant ESKAPE pathogens.

Results

A total of 443 articles were analyze

SUBMITTER: Guo S 

PROVIDER: S-EPMC12571837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature