Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala.

ABSTRACT:

Background

Basic neuroscience has identified dopamine and corticotropin-releasing hormone (CRH) systems and amygdala circuits as key contributors to drug and alcohol reward, craving, and relapse. However, directly targeting these systems has had no impact on the treatment of addictive disorders. CRH receptor 1 (CRHR1) and dopamine receptor D1 are both modulators of amygdala function. The intercalating cell masses (ITC) regulate intra-amygdala signal flow and are highly enriched in CRHR1 and D1. To date, interactions between these systems have not been extensively examined. We tested these interactions using a combination of in vivo pharmacology, genetic targeting and behavioral studies in rodents.

Methods

The impact of CRHR1 activation on D1 was demonstrated using i.

SUBMITTER: Broccoli L 

PROVIDER: S-EPMC12571840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature